Police were called to Corfield Street, Bethnal Green, on Sunday (May 5) to reports of a brawl taking place at about 8.20pm.
But when officers attended, a man, 38, was found with a stab injury and he died at the scene.
The Metropolitan Police says that officers are working to inform the man’s family and a formal identification is yet to take place.
A post-mortem examination will also be held in due course.
No arrests have yet been made as investigations into the attack continue and a crime scene remains in place.
Superintendent Alex Ogilvie, one of the senior officers responsible for policing in Tower Hamlets, said: “I recognise the impact this violent incident will have on the local community, especially as it happened in a residential street while many people would have been in their homes.
“We shall be supporting our colleagues in the Specialist Crime Command with their investigation, and you can expect to see officers in the area over the coming days.
“I encourage you to speak with them about anything you saw or heard, as well as any concerns you may have.”
Anyone with information or dashcam, doorbell or mobile phone footage is asked to call police via 101 quoting reference CAD 6482/05May, alternatively call Crimestoppers anonymously on 0800 555 111.
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