Police were called at 9.12pm to reports of a stabbing in Longshaw Road, Chingford.
Officers and paramedics from the London Ambulance Service and London’s Air Ambulance found the 17-year-old boy suffering from a stab wound.
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Despite the efforts of members of the public and emergency services, he died at the scene.
The boy’s next-of-kin have been informed.
Metropolitan Police officers arrested a 16-year-old boy and a 15-year-old boy at residential addresses in Chingford this morning (Wednesday, April 12) on suspicion of murder.
They have been taken to a north London police station where they remain in custody.
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Detective Chief Inspector Larry Smith said: “Our investigation is continuing at pace and this morning we made two arrests in connection with this tragic incident, which resulted in a teenager losing his life.
“However, our enquiries very much continue and I would appeal to anyone with information who is yet to speak to us to come forward.
“Your information, no matter how small you think it is, could help get justice for a grieving family.
“This incident has had a devastating impact on the victim’s friends and family and I’d ask for their privacy to be respected at this difficult time.”
Anyone who can help the investigation is asked to call the incident room on 020 8345 3985 or police on 101 quoting CAD 6358/10Apr.
You can also message @MetCC on Twitter.
To remain anonymous, contact the independent charity Crimestoppers on 0800 555 111 or visit crimestoppers-uk.org.