West Ham manager David Moyes has made six changes to his West Ham team to take on Genk at the London Stadium.
In goal Moyes has opted to once again start with Alphonse Areola in Europe with Lukasz Fabianski on the bench.
Vladimir Coufal was an injury doubt going into the match and is not included in the matchday squad, with Ryan Fredericks only just returning from his own injury absence Ben Johnson has been given the nod at right-back.
Aaron Cresswell has retained his spot with Arthur Masuaku coming back into the matchday squad as one of the replacements.
The two full-backs flank Craig Dawson and Issa Diop at the heart of the defence with the pair striking up a fine partnership in recent weeks.
In midfield, Moyes has opted against handing a rest to Tomas Soucek and Declan Rice with the pair once again lining up in the middle of the park.
Moyes has changed up the Hammers attacking quartet with Jarrod Bowen, Said Benrahma and Pablo Fornals dropping to the bench. Nikola Vlasic, Andriy Yarmolenko and Manuel Lanzini come into the team in their place behind lone striker Jarrod Bowen.
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The Hammers bench is a strong one with international experience in the form of Angelo Ogbonna, Kurt Zouma and Fornals joining Benrahma in reserve. Youngster Harrison Ashby has been handed a second successive spot in the matchday squad following his involvement against Everton on Sunday afternoon. The young Scot is joined by fellow U23 player Daniel Chesters.
West Ham XI: Areola, Johnson, Dawson, Diop, Cresswell, Rice, Soucek, Yarmolenko, Vlasic, Lanzini, Bowen
Subs: Fabianski, Randolph, Zouma, Ogbonna, Fredericks, Ashby, Chesters, Masuaku, Fornals, Noble, Benrahma